Lupus erythematosus - Lupus Eritematosus
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Ngenali lan nggolongake cutaneous lupus erythematosus (CLE) nyebabake tantangan diagnostik, mbedakake saka systemic lupus erythematosus kanthi keterlibatan kulit. Panaliten anyar nuduhake faktor genetik, lingkungan, lan imunologis sing ndasari CLE. Induksi obat khusus wis muncul minangka salah sawijining pemicu paling penting kanggo CLE. Perawatan kalebu terapi topikal lan sistemik, kalebu biologis sing janjeni (belimumab, rituximab, ustekinumab, anifrolumab, BIIB059) , kanthi khasiat sing dituduhake ing uji klinis.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) nyakup macem-macem masalah kulit, sawetara bisa uga ana hubungane karo masalah kesehatan sing luwih akeh. Iki dikategorikaké dadi macem-macem jinis, kayata acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE kalebu discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus minangka klompok penyakit otoimun sing bisa mengaruhi macem-macem bagean awak. Sawetara jinis, kayata systemic lupus erythematosus (SLE) , mengaruhi macem-macem organ, dene liyane, kayata cutaneous lupus erythematosus (CLE) , utamane mengaruhi kulit. Kita nggolongake macem-macem jinis CLE adhedhasar campuran tandha klinis, pemeriksaan jaringan, lan tes getih, nanging ana akeh variasi ing antarane individu. Masalah kulit asring berkembang amarga faktor kaya cahya srengenge, ngrokok, utawa obat-obatan tartamtu.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Penyebab lupus eritematosus (lupus erythematosus) ora jelas. Antarane kembar identik, yen siji kena pengaruh ana kemungkinan 24% sing liyane bakal kena. Hormon seks wanita, sinar matahari, ngrokok, kekurangan vitamin D, lan infeksi tartamtu uga diyakini bisa nambah risiko.
Pangobatan bisa uga kalebu NSAID, kortikosteroid, imunosupresan, hydroxychloroquine, lan methotrexate. Sanajan kortikosteroid efektif, panggunaan jangka panjang nyebabake efek samping.